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M. Sharon Stack

Dr. M. Sharon Stack received her PhD degree in Biochemistry from the University of Louisville, completed post-doctoral training in biochemical pathology at Duke University Medical Center, and served for several years as a Research Assistant Professor in Pathology at Duke.

In 1994, she joined the faculty in the Department of Cell & Molecular Biology at Northwestern University where she rose through the ranks to tenured Professor. While at Northwestern, Dr. Stack was also Program Leader of the Tumor Invasion, Metastasis and Angiogenesis Program of the NCI-designated RH Lurie Comprehensive Cancer Center (RHLCCC) and a member of the RHLCCC Executive Committee.

She joined the University of Missouri in 2007 as Professor and Vice Chair for Research in the Department of Pathology and Anatomical Sciences. She is currently (since 2011) Professor of Chemistry and Biochemistry and the Ann F. Dunne and Elizabeth Riley Director of the Harper Cancer Research Institute, University of Notre Dame.

Dr. Stack has served as a full member of the NIH/NCI Tumor Progression and Metastasis study section and on review panels for many other funding agencies, and is currently a member of the Department of Defense Ovarian Cancer Research Program (DOD OCRP) Integration Panel and Vision Setting Panel. [more]

Stack Lab Research Overview

The ability to invade host tissues and metastasize is the major cause of cancer-related death. During tumor invasion, metastasizing cells disrupt normal cell-cell and cell-matrix contacts and acquire a migratory, invasive phenotype. Thus modulation of cell-cell and cell-matrix adhesive events likely plays a critical role in tissue remodeling during tumor progression. Subsequent alterations in cellular architecture mediated by modified extracellular matrix (ECM) attachments induce expression of proteinases that degrade ECM proteins, facilitating migration through the modified tissue to establish metastatic foci and removing matrix constraints that normally limit proliferation. [more]


Partnerships and Collaborations


Harper Facebook

Thank you to everyone who joined us at the Notre Dame Women's Soccer game vs. Syracuse Women's Soccer! Congrats to the ND Women's Soccer team on their 2-0 victory! Also congratulations to HCRI's very own Dr. Thomas O'Sullivan, Assistant Professor of Electrical Engineering, on being recognized for his work on breast cancer during this breast cancer awareness game. Joining Dr. O'Sullivan was Mike Harrity, Senior Associate Athletics Director, Michael Casper, the Assistant Coach and his wife, Kerri Casper. ...

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Please join us on October 30th, 2017 from 11:30am - 2:00pm in the Harper Cancer Research Institute Parking lot for a blood drive. $5 will be donated to cancer research at HCRI for every unti of blood collected by The Medical Foundation. You can sign up at givebloodnow.com using the sponsor code: Irish. ...

HCRI Blood Drive

October 30, 2017, 11:30am - October 30, 2017, 2:00pm

Please join us on October 30th, 2017 from 11:30am - 2:00pm in the Harper Cancer Research Institute Parking lot for a blood drive. $5 will be donated to cancer research at HCRI for every unti of blood collected by The Medical Foundation. You can sign up at givebloodnow.com using the sponsor code: Irish.

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Human Papillomavirus
(HPV)-Associated
Oropharyngeal Cancer
(Hardcover & Kindle)

Daniel L. Miller (Editor)
M. Sharon Stack (Editor)
available on amazon.com


Ovarian Cancer book

Ovarian Cancer
Cancer Treatment and Research
(Hardcover)

M. Sharon Stack (Editor)
David A. Fishman (Editor)
available on amazon.com

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