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Refereed Journal Articles

Liu, Y, Stack, MS, Lakka, SS, Khan, AJ, Woodley, DT, Rao, JS, and Rao, CN (1999) Matrix Localization of TFPI-2/MSPI Involves Arginine-Mediated Ionic Interactions with Heparin and Dermatan Sulfate: Heparin Accelerates the Activity of TFPI-2/MSPI Towards Plasmin.  Archives Biochem. Biophys. 37, 112-118. [PDF]

Fishman, D.A., Kearns, A., Larsh, S., Enghild, J.J., and Stack, M.S.  (1999) Autocrine Regulation of  Growth Stimulation in Human Epithelial Ovarian Carcinoma by Serine Proteinase-Catalyzed Release of the Urinary-type Plasminogen Activator Amino Terminal Fragment.   Biochem. J.  341:765-769. [PDF]

Stack, M.S.,  Gately, S., Bafetti, L.M., Enghild, J.J., and Soff, G.A. Angiostatin Inhibits Endothelial and Melanoma Cellular Invasion by Blocking Matrix-Enhanced Plasminogen Activation (1999) Biochem. J. 340: 77-84. [PDF]

Moser, T.L., Stack, M.S. , Asplin, I., Enghild, J.J, Hojrup, P., Hubchak, S. Schnaper, H.W. and  Pizzo, S.V. (1999) Angiostatin Binds ATP Synthase on the Surface of Human Endothelial Cells..  Proc. Natl. Acad. Sci. USA 96:2811-2816.

Ellerbroek, S.M., Kearns, A.M., Bafetti, L.M., Fishman, D.A. and Stack, M.S. (1999) Ovarian  Carcinoma Regulation of Matrix Metalloproteinase-2 and Membrane Type-1 Matrix Metalloproteinase Through  beta1 Integrin.  Cancer Research 59: 1635-1641. [PDF]

Fishman, D.A., Kearns, A.M., Chilikuri, K., Bafetti, L.M., O’Toole, E.A., Georgacopoulos, J., Ravosa, M.J., and Stack, M.S. (1998) Metastatic Dissemination of Human Ovarian Epithelial Carcinoma is Promoted by  a2b1 Integrin-Mediated Interaction with Type I Collagen.  Invasion and Metastasis 18, 15-26.

Rao, C.N., Cook, B., Liu, Y., Chilukuri, K., Stack, M.S., Foster, D.C., Kisiel, W., and Woodley, D.T. (1998) HT-1080 Fibrosarcoma Cell Matrix Degradation and Invasion Are Inhibited by the Matrix-Associated Serine Protease Inhibitor TFPI-2/33 kDa MSPI.  Int. J. Cancer 76:749-756. [PDF]

Ellerbroek, S.M., Hudson, L.G. and Stack, M.S. (1998)  Proteinase Requirements of Epidermal Growth Factor Induced Ovarian Cancer Cell Invasion. Int. J. Cancer 78:331-337. [PDF]

Goldfinger, L.E., Stack, M.S., and Jones, J.C.R. (1998) Processing of Laminin-5 and its Physiological Consequences:  Role of Plasmin and Tissue-type Plasminogen Activator. J. Cell Biology 141:255-265. [PDF]

Thomas, V.A., Wheeless, C.J., Stack, M.S., and Johnson, D.A. (1998) Human Mast Cell Tryptase  Fibrinogenolysis: Kinetics, Anticoagulation Mechanism and Cell Adhesion Disruption.  Biochemistry, 37:2291-2290. [PDF]

Bafetti, L.M., Young, T.N., Itoh, Y. and Stack, M.S.  (1998) Intact Vitronectin Induces Matrix  Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinases-2 Expression and Enhanced Cellular Invasion by Melanoma Cells.  J. Biol. Chem.273:143-149. [PDF]

Xu, F.J., Stack, M.S., Boyer, C., O’Briant, K., Whitaker, R., Mills, G.B., Yu, Y.H., Bast, R.C., Jr. (1997) Heregulin and Agonistic anti-p185 (c-erbB2) Antibodies Inhibit Proliferation but Increase Invasiveness of Breast Cancer Cells That Overexpress p185 c-erbB2: Increased Invasiveness May

Fishman, D.A., Chilukuri, K., and Stack, M.S. (1997) Biochemical Characterization of Primary Peritoneal Carcinoma Cell Adhesion, Migration and Proteinase Activity. Gynecologic Oncology, 67:193-199. [PDF]

Gately, S. Twardowski, P., Stack, M.S., Cundiff, D.L., Weiss, I., Grella, D., Castellino, F.J.,  Enghild, J.J., Kwaan, H.C., Lee, F., Kramer, R.A., Volpert, O., Bouck, N.,  and Soff, G.A. (1997)  The Mechanism of Cancer-Mediated Conversion of Plasminogen to the Angiogenesis Inhibitor Angiostatin.  Proc. Nat. Acad. Sci. 94, 10868-10872. [PDF]

Fishman, D.A., Bafetti, L.M., Banionis, S., Kearns, A.S., Chilukuri, K., and Stack, M.S. (1997) Production of Extracellular Matrix Degrading Proteinases by Primary Cultures of Human  Epithelial Ovarian Carcinoma Cells. Cancer 80:1457-63. [PDF]

Tolsma, S.S., Stack, M.S. and Bouck, N. (1997) Lumen Formation and Other Angiogenic Activities of Cultured Capillary Endothelial Cells Are Inhibited by Thrombospondin-1. Microvascular Research 54:13-26. [PDF]

Fishman, D.A., Bafetti, L.M., and Stack, M.S. (1997) Membrane-Type Matrix Metalloproteinase  Expression and Matrix Metalloproteinase Activation in Primary Human Ovarian Epithelial Cells.  Invasion and Metastasis, 16:150-159.

Gately, S., Twardowski, P., Stack, M.S., Patrick, M. Boggio, L., Cundiff, D.L., Schnaper, H.W., Madison, L., Volpert, O., Bouck, N., Enghild, J., Kwaan, H.C., and Soff, G. (1996) Human Prostate Carcinoma Cells Express Enzymatic Activity that Converts Human Plasminogen to the Angiogenesis Inhibitor Angiostatin.  Cancer Res. 56, 4887-4890.

Stack, M.S., Itoh, Y., Young, T.N. and Nagase, H. (1996) Fluorescence Quenching Studies of Matrix Metalloproteinases (MMPs):  Evidence for Structural Rearrangement of the proMMP- 2/TIMP-2 Complex upon Mercurial Activation.  Arch. Biochem. Biophys. 333:163-169. [PDF]

Moser, T.L., Pizzo, S.V. Bafetti, L., Fishman, D., and Stack, M.S.  (1996) Evidence for Preferential Adhesion of Ovarian Epithelial Carcinoma Cells to Type I Collagen Mediated by the alpha2beta1 Integrin. Int. J. Cancer, 67:695-701.

Young, T.N., Rodriguez, G.C., Bast, R.C., Pizzo, S.V.,and Stack, M.S. (1996) Characterization  of Gelatinases Linked to Invasion in Ovarian Carcinoma:  Purification of Matrix Metalloproteinase 2.  Gynecologic Oncology 62, 89-99. [PDF]

Stack, M.S., Rinehart, A. and Pizzo, S.V. (1995) Comparison of Plasminogen Binding and Activation on Extracellular Matrices Derived from Smooth Muscle and Endothelial Cells. European J. Biochem. 226, 937-943.

Moser, T.L., Enghild, J.J., Pizzo, S.V. and Stack, M.S. (1995) Specific Binding of Urinary-type  Plasminogen Activator (u-PA) to Vitronectin and its Role in Mediating u-PA-Dependent Adhesion of  U937 Cells. Biochemical Journal 307, 867-873.

Young, T.N., Pizzo, S.V. and Stack, M.S. (1995) A Plasma Membrane-Associated Component of Ovarian Adenocarcinoma Cells Enhances the Catalytic Efficiency of Matrix Metalloproteinase-2.  J. Biol. Chem. 270, 999-1002. [PDF]

Young, T.N., Rodriguez, G., Moser, T., Bast, R.C., Pizzo, S.V. and Stack, M.S. (1994) Co-ordinate Expression of Urinary-type Plasminogen Activator (u-PA) and its Receptor Accompanies Malignant Transformation of Ovarian Epithelium. Am. J. Obstet. Gynecol. 170, 1285-1296.

Stack, M.S. and Johnson, D.A. (1994) Human Mast Cell Tryptase Activates Single Chain Urinary-type Plasminogen Activator (Prourokinase). J. Biol. Chem. 269, 9416-9419. [PDF]

Stack, M.S. and Pizzo, S.V. (1994) The Effect of Substituted Laminin-Derived Peptides on the Conformation and Activation Kinetics of Human Plasminogen.  Arch. Biochem. Biophys. 309, 117-122. [PDF]

Moser, T.L., Young, T.N., Rodriguez, G., Pizzo, S.V., and Stack, M.S. (1994) Secretion of   Extracellular Matrix-Degrading Proteinases is Enhanced in Ovarian Epithelial Carcinoma. Int. J.  Cancer 56, 552-559. [PDF]

Stack, M.S. and Pizzo, S.V. (1993) Modulation of Tissue Plasminogen Activator-Catalyzed Plasminogen Activation by Synthetic Peptides Derived from the Amino-Terminal Heparin Binding Domain of Fibronectin.  J. Biol. Chem. 268, 18923-18927. [PDF]

Moser, T.L., Enghild, J.J., Pizzo, S.V. and Stack, M.S. (1993) The Extracellular Matrix Proteins Laminin and Fibronectin Contain Binding Domains for Human Plasminogen and Tissue Plasminogen Activator.  J. Biol.Chem. 268, 18917-18923.

Stack, M.S., Gray, R.D. and Pizzo, S.V. (1993) Modulation of Murine B16F10 Melanoma  Plasminogen Activator Production by a Synthetic Peptide Derived from the Laminin A Chain. Cancer Research 53, 1998-2004.

Young, T.N., Edelberg, J.M., Stack, M.S. and Pizzo, S.V. (1992) Ionic Modulation of the Effects of Heparin on Plasminogen Activation by Tissue Plasminogen Activator.  Arch. Biochem. Biophys. 296, 530-538.

Stack, M.S., Pizzo, S.V. and Gonzalez-Gronow, M. (1992) Effect of Desialylation on the Biological Properties of Plasminogen.  Biochemical Journal 284, 81-86. [PDF]

Stack, M.S., Moser, T., and Pizzo, S.V. (1992) Binding of Human Plasminogen to Basement Membrane (type IV) Collagen. Biochemical Journal 284, 103-108.

Stack, M.S., Emberts, C., and Gray, R.D. (1991) Application of N-Carboxyalkyl Peptides to the Inhibition and Affinity Purification of the Porcine Matrix Metalloproteinases Collagenase, Gelatinase, and Stromelysin.  Arch. Biochem. Biophys. 287, 240-249.

Gonzalez-Gronow, M., Stack, M.S., and Pizzo, S.V. (1991)  Plasmin Binding to the Plasminogen Receptor Enhances Catalytic Efficiency and Activates the Receptor for Subsequent Ligand Binding. Arch. Biochem. Biophys. 286, 625-628.

Stack, M.S., Gray, R.D. and Pizzo, S.V.  (1991) Modulation of Plasminogen Activation and Type IV Collagenase Activity by a Synthetic Peptide Derived From the Laminin A Chain.  Biochemistry 30, 2073-2077.

Stack, M.S., Gonzalez-Gronow, M., Pizzo, S.V. (1991) The Effect of Divalent Cations on the  Conformation and Function of Human Plasminogen.  Arch. Biochem. Biophys. 284, 58-62.

Stack, M.S., Gonzalez-Gronow, M., Pizzo, S.V. (l990) Regulation of Plasminogen Activation by Components of the Extracellular Matrix.  Biochemistry  29, 4966-4970.

Stack, M.S. and Gray, R.D. (1990) The Effect of pH, Temperature and D2O on the Activity of Porcine Synovial Collagenase and Gelatinase. Arch. Biochem. Biophys. 281, 257-263.

Darlak, K., Miller, R.B., Stack, M.S., Spatola, A.R., and Gray, R.D. (l990) Thiol-based Inhibitors  of Mammalian Collagenase: Substituted Amide and Peptide Derivatives of the Leucine Analogue 2[(R,S)-Mercaptomethyl]-4-methylpentanoic acid. J. Biol. Chem. 265, 5199-5205.


Book Chapters and Invited Reviews

Ellerbroek, S.M. and Stack, M.S. Membrane-Associated Matrix Metalloproteinases in Metastasis (Review) (1999) Bioessays 21: 940-949. [PDF]

Stack, M.S., Ellerbroek, S.M. and Fishman, D.A. (1998) The Role of Proteolytic Enzymes in the Pathology of Ovarian Carcinoma (Review), Int. J. Oncology 12: 569-576.

Stack, M.S., Madison, E.L., and Pizzo, S.V. (1995) Tissue-Type Plasminogen Activator, in Molecular Basis of Thrombosis and Hemostasis, Roberts, H.R. and High, K.A., eds., Marcel  Dekker Inc., pp. 479-494


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